Target Organism: Neisseria meningitidis (sodC), Streptococcus pneumoniae (ply), Haemophilus influenzae (hpd), SPC
Intended Use: The BioGX Bacterial Meningitis NSH – OSR for BD MAX™ is an automated in vitro diagnostic test reagent. The open system reagent (OSR) is used for the multiplex qualitative detection of DNA from Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae, and a DNA sample processing control (abbreviated NSH and SPC, respectively).
Clinical Significance: The majority of bacterial meningitis cases are caused by Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, Group B Streptococcus, and Listeria monocytogenes. Incidence of bacterial meningitis is seen mostly in infants, of which roughly 80 cases per 100,000 people are seen annually in infants younger than 2 months as of 2007. Acute bacterial meningitis is very serious and can be deadly in an estimated 10-20% of cases. While most people with meningitis recover, permanent disabilities such as brain damage, hearing loss, and learning disabilities can result from the infection. In the United States, about 4,100 cases of bacterial meningitis including 500 deaths, occurred each year between 2003-2007.